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KMID : 0948320050050020172
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Konyang Medical Journal
2005 Volume.5 No. 2 p.172 ~ p.177
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Nifedipine Versus Ritodrine Hydrochloride for the Treatment of Preterm Labor
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Lee Ji-Young
Lee Sung-Ki
Ko Kyong-Og
Song Dong-Keum
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Abstract
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Objective: The purpose of this study was to evaluate the efficacy and safety of oral nifedipine and ritodrine hydrochloride on the management of preterm labor.
Methods: Patients between 20 and 37 weeks’ gestation with documented preterm labor were randomly assigned to receive oral nifedipine (n=31) or ritodrine hydrochloride (n=57) as initial tocolytic therapy. Among patients (n=29) who failed to tocolysis with ritodrine hydrochloride, 26 subjects had oral nifedipine additionally. Success rate, maternal- fetal side effects, and fetal outcome were assessed by the principal outcome.
Results: There were no significant differences in maternal demographic characteristics between the groups. Successful tocolysis, defined as cessation of uterine contractions , was observed in 28 (49.1%) in the 57 ritodrine hydrochloride group and 12(38.7%) in the 31 nifedipine group (p=0.274). The success rate of ritodrine hydrochloride with nifedipine group was 26(92.3%). The days gained in uterus was not statistically difference between the ritodrine hydrochloride group and nifedipine group(p=0.395). There were significantly fewer maternal side effects in the nifedipine group.
Conclusion: Oral nifedipine and ritodrine hydrochloride each had similar results as tocolytic effects and safety. Patients who received ritodrine hydrochloride with added nifedipine had more effective tocolytic efficacy.
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KEYWORD
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nifedipine, preterm labor, ritodrine hydrochloride
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